Abstract: The presence of biofilms in chronic wounds has been associated with impaired wound repair and changes in inflammatory profiles. There is a great need for the evaluation of wound dressings in suitable in vitro biofilm-infected wound models. This study has demonstrated the effectiveness of an innovative anti-biofilm agent against S. aureus biofilms in a 3-D in vitro skin model. The effect of this agent on in vitro biofilms was demonstrated using CLSM. Furthermore, the use of the anti-biofilm agent reduced the secreted levels of IL-6 in the biofilm-infected wound model. Cytotoxicity screening has showed that this agent is not cytotoxic to cells and therefore should be considered a potential treatment in biofilm-infected wounds.
Publication Details:
Author(s): Percival, S.L.; Hunt J.A.; Chen, R.; Suleman, L.
Year: SAWC 2017 spring. San Diego, CA, 05-10 April, 2017.
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